CNS Demyelination Diseases Following Exposure to Urban Air Pollution

Epidemiology findings show that exposure to urban air pollutants as a source of oxidative stress and neuroinflammation is associated with the Central Nervous System (CNS) demyelinating diseases, such Multiple Sclerosis (MS). An autoimmune response involving increased inflammation demyelination in CNS leads pathophysiology MS, which more common adult young females. Particulate Matter (PM), including fine particles (PM <2.5?m, PM 2.5) very <0.1?m, 0.1), transition metals, ozone are potent or oxidant capable producing Reactive Oxygen Species (ROS). Redox-sensitive pathways can be caused by stress, leading various biological processes, other harmful outcomes brain. Exposure Diesel Exhaust Particles (DEPs) mediates significant alterations myelination across regions There also an increase ROS production DEPs exposed mice. Thus, targeting useful strategy eliminate obvious symptoms diseases. Overall, current mini-review, we examined nanoparticles MS.